The father shall be divided against the son, and the son against the father; the mother against the daughter, and the daughter against the mother; the mother in law against her daughter in law, and the daughter in law against her mother in law. 12:53
Peter, James, and John leave everything (including their families) to follow Jesus.
(See 4:38 for reference to Peter's wife.) 5:11
Jesus, when told that his mother and brothers want to see him, ignores and insults them by
saying that his mother and brothers are those who hear the word of God and do it. 8:20-21
Jesus insults his mother (the Most Holy Blessed Virgin Mary). 11:27-28
Abandon your wife and family for Jesus and he'll give you a big reward. 18:29-30