Peter, James, and John leave everything (including their families) to follow Jesus.
(See 4:38 for reference to Peter's wife.) 5:11
Jesus, when told that his mother and brothers want to see him, ignores and insults them by
saying that his mother and brothers are those who hear the word of God and do it. 8:20-21
Jesus insults his mother (the Most Holy Blessed Virgin Mary). 11:27-28
Abandon your wife and family for Jesus and he'll give you a big reward. 18:29-30